Exploring Skin Longevity Pathways: Rosa hybrid Extract-Mediated AMP-Activated Protein Kinase Activation, Antioxidant, and Autophagic Mechanisms in Human Keratinocytes

The skin, as the body’s outermost layer, constantly faces environmental stressors that accelerate the aging process. Factors such as ultraviolet radiation (UVR) and pollution, including Benzo[a]pyrene (BAP), induce oxidative damage, impair skin homeostasis, and lead to the accumulation of damaged…