Astragalus, a genus with over 2000 species, has been used in traditional Chinese medicine for centuries. Known for its diverse health benefits, is believed to enhance skin health. Astragalus gombiformis, for example, has shown UV-absorbing and anti-inflammatory properties, while Astragalus membranaceus reduces DNA damage from UV exposure.
Astragalus derivatives are now commonly found in cosmetic products, with claims of benefits such as deep moisture, improved skin elasticity, and treatment for skin conditions like acne and psoriasis. Given the plant’s growing presence in the skincare industry and its potential for misleading marketing claims, researchers independently consolidated current research on the efficacy of topical Astragalus for skin health and dermatologic conditions.
KEY FINDINGS
- Alopecia: Astragaloside IV, a component of Astragalus membranaceus, promoted hair regrowth in mice by inhibiting apoptotic pathways associated with hair loss.
- Atopic Dermatitis: Astragalus membranaceus reduced skin thickening and inflammation in mice models, likely due to immunomodulatory effects that restore NF-κB expression and suppress Th2-mediated inflammation.
- Contact Dermatitis: Topical application of Astragalus membranaceus showed a reduction in symptoms similar to dexamethasone, including reduced mast cell infiltration and epidermal thickness.
- Wound Healing: Astragalus membranaceus and Astragaloside IV accelerated wound healing by promoting angiogenesis and reducing inflammation. Studies on diabetic and non-diabetic mice showed significant improvements in wound closure and skin regeneration.
- Dermatophytosis: Astragalus verus olivier showed antifungal effects against Trichophyton verrucosum infection in guinea pigs, with a concentration above 20% being most effective.
The reviewed studies indicate that Astragalus has beneficial effects on skin conditions in animal models, particularly through immunomodulation and angiogenesis. However, none of these studies tested its effects on humans. While some studies showed Astragalus was less effective than standard treatments, others found it superior in wound healing.
Limitations include the lack of human trials and reliance on artificially induced conditions in animals, which may not represent effects in humans with naturally occurring skin conditions. Future research should compare Astragalus to established treatments and assess its long-term efficacy in humans.
Link to the study: https://tinyurl.com/4pj7uxec
