The cosmetic industry is continuously seeking innovative formulations that can effectively address skin aging and damage while utilizing sustainable and high-quality raw materials. Traditional cosmetic products often fall short in delivering active ingredients to the deeper layers of the skin due to their larger particle size, leading to limited efficacy. To overcome these limitations, nanoemulsions have emerged as a promising solution, offering enhanced skin penetration, improved stability, and better sensory attributes. Sesame Seed Oil (SO) and Raspberry Seed Oil (RO) have gained popularity in cosmetics due to their antioxidant, moisturizing, and anti-inflammatory properties. This research explores the development of nanoemulsions containing SO and RO using a low-energy method to enhance their delivery and efficacy in skincare applications.
Methods:
The study involves formulating nanoemulsions containing Sesame Seed Oil (SO) and Raspberry Seed Oil (RO) using the low-energy method. The antioxidant activities of SO and RO were evaluated in vitro. Ternary phase diagrams were used to determine the optimal formulation5…. The Ostwald ripening instability process was studied, and the formulations were evaluated in vitro using the HET-CAM method to assess irritation potential.
Key Findings:
•Antioxidant Activity:
◦The IC50 values for SO and RO were found to be 310.94 μL/mL and 34 μL/mL, respectively, indicating that RO has a higher antioxidant capacity.
◦Chemiluminescence tests showed that RO exhibited twice the antioxidant activity of SO.
◦Nanoemulsions A and F.80 demonstrated significant antioxidant activity, with inhibition percentages of 68.71% and 67.75%, respectively.
•Formulation and Stability:
◦The required HLB value for SO was determined to be 8.0 using polysorbate 80 and sorbitan monooleate.
◦Nanoemulsions with globule sizes of 50 nm (A) and 200 nm (F.80) were obtained using PEG 15 castor oil and PEG 30 castor oil, respectively.
◦The lowest Ostwald ripening index (1.33 × 10-22 m3 s-1) was achieved with SO nanoemulsions containing PEG 15 and PEG 30 castor oil at temperatures of 85 °C and 75 °C, respectively.
◦The addition of co-surfactants PEG 40 castor oil and PEG 54 castor oil aided in the formation of stable SO nanoemulsions with RO additives.
•In Vitro Evaluation:
◦HET-CAM assay revealed that the nanoemulsions and surfactants were only slightly irritating, suggesting their potential for use in cosmetic products.
This research successfully formulated stable nanoemulsions containing sesame seed oil and raspberry seed oil using a low-energy method. The study highlights the novelty of utilizing SO and RO in nanoemulsion form to enhance their antioxidant and moisturizing properties for skincare applications. The low Ostwald ripening index and the non-irritating nature of these nanoemulsions indicate their potential for prolonged stability and safe use in cosmetics. Future research could explore the in vivo efficacy of these nanoemulsions and investigate the synergistic effects of combining SO and RO with other active ingredients. These findings contribute to the development of advanced cosmetic formulations that can effectively address skin aging and promote overall skin health.
Link to the study: https://www.mdpi.com/2079-9284/12/2/32
