Cellulite—also called Edematous Fibrosclerotic Panniculopathy (EFP), gynoid lipodystrophy, or “orange peel” skin—is a common condition affecting up to 90% of post-pubertal women, especially on the thighs and buttocks. Though harmless, its visual presentation can negatively affect self-esteem. Current non-invasive treatments offer only temporary cosmetic results, while more effective procedures tend to be invasive, costly, or uncomfortable. To bridge this gap, researchers evaluated a novel thermogenic cream-gel designed to improve cellulite appearance through dual thermal action and bioactive plant compounds like caffeine and genistein.
Methods
A prospective, single-center study enrolled 56 women aged 18–55 with symmetrical grade II or III cellulite. Participants applied the topical cream-gel twice daily for 8 weeks to thighs and buttocks using circular massage. Efficacy was assessed through 3D skin imaging (ANTERA® system), dermatologist clinical grading (EFP scale and pinch test), and patient self-assessment questionnaires. The product’s tolerability and adverse events were also monitored throughout the study.
Key Findings
- Skin Profilometry:
A 23.5% mean reduction in skin indentation volume was observed by week 8. The total measured volume (SM4) dropped from 74.50 mm³ at baseline to 65.19 mm³ (p < 0.001). - Clinical Grading:
Cellulite severity dropped by an average of 1.1 points on the clinical scale. Ten participants improved from grade 2 or 3 to grade 1. EFP scale and pinch test results showed statistically significant improvements. - Patient Satisfaction:
91% were pleased with the product’s texture and application. 85.7% reported visible improvements, and overall satisfaction reached 83%, with no reports of dissatisfaction. - Safety Profile:
Only two participants (3.5%) experienced mild sensitivity. No serious adverse events occurred. Most participants tolerated the product well with no complaints of discomfort.
This study offers promising evidence that a non-pharmacological, over-the-counter thermogenic cream-gel can significantly improve the appearance of moderate to severe cellulite. When used with massage, the formulation showed clinical and aesthetic benefits, high user satisfaction, and minimal side effects. These outcomes rival those of certain energy-based treatments, without their cost or invasiveness. While the absence of a placebo group limits the ability to isolate active effects, the findings support the product’s potential as an accessible and consumer-friendly option for managing cellulite at home. Further placebo-controlled, long-term studies with histological analysis are warranted to better understand the cream-gel’s mechanisms.
Link to the study: https://www.mdpi.com/2079-9284/12/4/155
