The prevalence of diabetes mellitus is increasing globally, with diabetic foot ulcers (DFU) being a major complication that often resulted in severe outcomes, including amputations and reduced life expectancy. Foot care with humectants could help improve foot health and prevent ulceration.
This study aimed to evaluate the effects of humectant-containing and humectant-free creams on xerosis (dry skin) in individuals with diabetes, providing insights for effective DFU prevention strategies.
Methods
Participants with diabetes were recruited to receive one of the two intervention humectant-creams , while the other foot was treated with a humectant-free cream. The study followed a double-blind design. Xerosis severity was measured at baseline, two weeks, and four weeks using the Xerosis Severity Scale (XSS). Secondary outcomes included assessments of skin barrier integrity through trans-epidermal water loss (TEWL), skin hydration, pH levels, quality of life, macrocirculation, and neuropathy. A total of 98 participants were targeted to ensure robust statistical analysis.
Key Findings
- Primary Outcome:
- Reduction in xerosis, as measured by the XSS score, was observed over a four-week application period with humectant-containing creams compared to the humectant-free cream.
- Foot dryness was documented and validated through dermatologist evaluations based on digital photographs.
- Secondary Outcomes:
- Skin barrier integrity, as indicated by reduced TEWL, and improvements in skin hydration were noted.
- Skin surface pH measurements suggested a healthier balance of host-microbiota interaction.
- Enhanced quality of life was recorded based on EuroQoL 5D outcomes.
- Improved macrocirculation and neuropathy measures were also noted, adding to the overall understanding of foot health in persons with diabetes.
Researchers, through this study, provided novel insights into skincare routines for diabetics.
Link to the study: https://tinyurl.com/4k494js9
