Transdermal actives delivery vesicular systems have long been explored for their potential to deliver therapeutic agents efficiently, non-invasively, and directly to the target site. This approach is particularly crucial for addressing skin health, where preserving the integrity of the stratum corneum—the skin’s protective barrier—is paramount. However, delivery technologies face significant challenges:
- Liposomes, one of the earliest systems, often suffer from poor stability and limited skin penetration due to their inability to interact effectively with the lipid structure of the skin.
- Niosomes, Transfersomes, and Ethosomes improve penetration but lack the controlled release capabilities needed for sustained therapeutic effects.
- Traditional systems frequently result in active ingredient degradation during delivery, reducing their efficacy and shelf life.
These shortcomings necessitate a delivery platform that can mimic the skin’s lipid matrix, enhance penetration, and protect active ingredients without compromising the skin barrier.
Cetosomes™, a novel patented technology by Cymbiotics, addressesd these challenges by providing a dynamic, stable, and customizable solution designed specifically for topical and transdermal applications.
What Are Cetosomes™?
Cetosomes™ are nanoparticles vesicles meticulously designed from cetylated fatty esters. Unlike traditional lipid-based nanoparticles, Cetosomes™ are unique in their proprietary structure and self-assembly mechanisms, powered by advanced cetylation chemistry. This enables:
- Enhanced penetration of active ingredients.
- Protection of therapeutic agents during delivery.
- Controlled release, ensuring sustained effects.
This revolutionary transdermal vesicular active delivery system, patented exclusively by Cymbiotics, combines versatility, adaptability, and precision to elevate topical and transdermal formulations.
Unveiling the Unique Advantages of Cetosomes™
Cetosomes™ address the key challenges in transdermal actives delivery by offering:
- Gentle Delivery: By mimicking the skin’s lipid structure, Cetosomes™ facilitate enhanced penetration of bioactive molecules without causing skin disruption or requiring puncturing procedures. The formulations are designed to protect the disruption of the stratum corneum’s natural barrier function. This gentle approach minimizes the risk of adverse skin reactions
- Stability and Protection: Encapsulation within
- Controlled and Sustained Release: Premature actives release is prevented in part through affinities between the actives and core components of the Cetosomes™. This indicates that the Cetosome™ structure is designed to hold onto the actives until it reaches the target site, preventing the actives from being released too early.
- Customizability: The adaptable nature of Cetosome™ technology allows for optimization based on the specific needs of different formulations and active ingredients.
Dynamic Structure of Cetosomes™
The remarkable efficacy of Cetosomes™ stems from their innovative and adaptive structure, which dynamically responds to the surrounding formulation environment:
- Core and Mantle Design:
- The core is made up of cetylated fatty esters, cetyl and, or stearyl alcohols, and surfactants, which form the stable inner matrix for encapsulating active ingredients.
- The mantle layer consists of polar solvents and additional surfactants, offering flexibility in interacting with various mediums.
- Zeta Potential for Stability: Cetosomes™ exhibit a net negative zeta potential, preventing aggregation and ensuring long-term stability in different varying conditions.
Versatility of Cetosome™ Technology
The adaptability of Cetosomes™ make them invaluable across a range of applications:
- Custom Encapsulation: By altering the hydrophilic-lipophilic balance, Cetosomes™ can optimize encapsulation for various active molecules, ensuring compatibility and efficacy.
- Surface Modifications: Cetosomes™ temporarily disrupt the stratum corneum to enhance actives permeation without causing permanent damage.
Conclusion
Cetosomes™ have redefined topical and vesicular transdermal actives delivery systems. With their unique structure, customizability, and dynamic adaptability, they overcome the long-standing challenges of bioavailability, stability, and therapeutic efficacy. By bridging gaps in traditional delivery methods, Cetosomes™ offer patient-friendly, non-invasive, and effective solutions for a wide range of therapeutic applications.
References:
- United States Patent – Transdermal delivery of medicaments with combinations of cetylated fatty ester penetrant complexes
Patent No: US 8,394,759 B2
Link: https://patents.google.com/patent/US8394759B2
- United States Patent – Topical dermal delivery compositions using self-assembling nanoparticles with cetylated components
Patent No: US 9,084,818 B2