Retinol is a vital derivative of Vitamin A used extensively to treat skin pathologies such as acne, psoriasis, and photodamage due to its ability to regulate cellular proliferation and inflammation. However, its clinical efficacy is severely hampered by its low…
The skin barrier, primarily located in the stratum corneum, is the body’s first line of defense against external stressors and essential for preventing transepidermal water loss. Ceramides are the central lipid components required for the lamellar organization of this barrier;…
Psoriasis (PsO) and atopic dermatitis (AD) are the most prominent immune-mediated inflammatory skin diseases, traditionally viewed as polar opposites in their underlying pathology. While PsO is primarily driven by Th17 dysregulation, AD is characterized by a Th2 imbalance. With the…
Post-oncologic skin is characterized by significant structural and functional impairments, including delayed epidermal turnover, compromised barrier integrity, and chronic inflammation resulting from chemotherapy and radiotherapy. These treatments target rapidly dividing cells, inadvertently damaging healthy skin components and inducing mitochondrial dysfunction…
The commercial success of cosmetic products is heavily reliant on their sensory characteristics, such as spreadability and non-stickiness, which dictate consumer preference and emotional response. Traditionally, these properties are evaluated through human panels, but this approach is often hindered by…
Facial hyperpigmentation, which affects over 40% of adults aged 30–50, is a prevalent dermatological concern that often leads to significant psychological distress, including anxiety and social withdrawal. While traditional treatments like hydroquinone and other tyrosinase inhibitors exist, they are frequently…
Skin hydration is a fundamental indicator of cutaneous health and the integrity of the stratum corneum (SC) barrier. Skin dryness is a significant clinical issue because it not only compromises the epidermal barrier, leading to increased transepidermal water loss (TEWL),…
Sensitive skin is a widespread global condition, affecting 30%–50% of the population, and is particularly prevalent in Asian skin, which often exhibits higher transepidermal water loss and reactivity compared to Caucasian skin. While topical retinoids are the clinical standard for…
The dermatological field faces a growing challenge in protecting skin against oxidative stress, which contributes to premature aging, inflammatory conditions, and various infections. While synthetic agents are available, there is a significant shift toward natural, plant-derived compounds due to their…
Atopic dermatitis (AD) is a chronic, inflammatory skin condition that significantly impairs quality of life, often requiring systemic biologic therapy like lebrikizumab or dupilumab when topical treatments fail. While both biologics have shown efficacy in separate trials when combined with…