The global healthcare system faces a critical challenge due to the rapid rise of antimicrobial resistance (AMR) and the emergence of “superbugs” that evade conventional synthetic antibiotics. If left unaddressed, AMR is projected to cause approximately 10 million deaths annually…
Plant-derived essential oils are increasingly recognized for their antimicrobial, antioxidant, and enzyme-inhibitory activities, making them valuable for cosmetic and dermatological applications. Specifically, the essential oil from Hedychium coronarium (white ginger lily) contains monoterpenoids like eucalyptol, which are effective against enzymes…
Acne vulgaris is a chronic inflammatory skin disorder that significantly impacts the psychosocial well-being of adolescents and adults globally. While multifactorial, its development is driven by the hyperproliferation of bacteria, most notably Cutibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. However,…
Glycolic acid (GA) is a premier alpha-hydroxy acid used in cosmetics for exfoliation and collagen synthesis stimulation; however, its effectiveness is hindered by its hydrophilic nature, which restricts penetration through the lipophilic stratum corneum. Furthermore, clinical use of GA often…
Aging is a natural biological process that has become a significant global health concern, particularly in tropical regions like Indonesia where high ultraviolet (UV) radiation accelerates skin aging through DNA damage and mitochondrial dysfunction. While synthetic anti-aging agents like retinoids…
Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by eczematous lesions and intense itching, which imposes a significant physical, psychological, and economic burden on patients and their caregivers. While mild cases are typically managed with topical treatments and…
The cosmetic industry is increasingly focused on addressing skin aging, cutaneous inflammation, and hyperpigmentation, which are often driven by environmental stressors like UV radiation and oxidative stress. Skin aging is primarily caused by the degradation of collagen and elastin by…
The accumulation of agro-industrial waste from winemaking, specifically grape pomace, presents a significant environmental challenge, yet these residues remain a rich source of bioactive polyphenols and antioxidants. Simultaneously, the cosmetic industry is shifting toward “green cosmetics,” seeking sustainable, natural ingredients…
The traditional scientific focus on gene therapies and genetic variants as the primary drivers of health and disease has often overlooked the critical role of proteins and epigenetics. Research indicates that “proteostasis collapse”—the accumulation of damaged, misfolded, or oxidized proteins—is…
Niacinamide (NIA) is a cornerstone ingredient in dermatology, valued for its ability to reduce transepidermal water loss (TEWL), improve skin elasticity, and manage inflammatory conditions like acne and rosacea. However, achieving efficient transdermal delivery of NIA is difficult because its…