Alopecia areata (AA) is a T-cell-mediated autoimmune disease characterized by hair loss, and researchers are increasingly investigating the gut microbiome as a potential therapeutic target. The gut microbiome consists of trillions of microorganisms that play a critical role in developing…
Ozone layer depletion has significantly increased the levels of ultraviolet B (UVB) radiation reaching the Earth’s surface, posing a severe threat to human skin. Prolonged exposure to UVB triggers oxidative stress, DNA lesions, and the overproduction of reactive oxygen species…
Acne vulgaris is a chronic inflammatory skin disorder affecting approximately 85% of individuals aged 12 to 24, characterized by the obstruction of hair follicles and potential for long-term physical and psychological scarring. While traditional treatments like topical retinoids or systemic…
Vitamin D3 deficiency is a global health concern affecting approximately half the world’s population, as humans require significant UVB exposure to produce sufficient amounts. Deficiency can aggravate dermatological diseases such as atopic dermatitis and psoriasis by weakening the skin’s barrier…
Cutaneous photoaging involves visible manifestations like wrinkles and texture alterations that significantly impact an individual’s psychosocial well-being, often leading to decreased self-esteem and social anxiety. While retinoids, particularly tretinoin, are considered the cornerstone of anti-aging therapy due to their ability…
Edible insects, specifically crickets, have emerged as sustainable and nutrient-dense alternatives to traditional livestock, offering high protein content and various bioactive peptides with antioxidant and anti-inflammatory properties. Despite their promise as natural cosmetic ingredients for skin-brightening and anti-aging, the direct…
The widespread use of chemical sunscreens is driven by their ability to protect skin from ultraviolet (UV) radiation; however, they often offer limited sun protection factor (SPF) and insufficient coverage for broad-spectrum UV radiations, particularly UVA1 (340–400 nm). Additionally, chemical…
Epidermal Growth Factor (EGF) is a critical protein for skin health, promoting collagen synthesis, wound healing, and anti-aging through the stimulation of cell proliferation. However, its topical application is significantly hindered by its hydrophilic nature and large molecular size, which…
Stem cells have become central to modern regenerative medicine and dermatology due to their unique abilities to self-renew and differentiate into diverse specialized cell types. However, the use of certain stem cell types can be hindered by ethical concerns, while…
The escalating prevalence of antimicrobial resistance (AMR) in skin bacteria, particularly Cutibacterium acnes and Staphylococcus epidermidis, has become a significant global clinical concern due to the widespread use of antibiotics in treating acne vulgaris. While high resistance rates are well-documented…