Psoriasis is a prevalent chronic, immune-mediated inflammatory skin condition that manifests clinically with red, swollen, and scaly patches or plaques. It is characterized fundamentally by the hyperproliferation of keratinocytes and the dysregulation of cytokine pathways involving various immune cells. Psoriasis…
Skin aging and pigmentation disorders are fundamentally driven by oxidative stress, which is often accelerated by external environmental factors such as UV irradiation and air pollutants. This leads to the generation of reactive oxygen species (ROS) that initiate molecular damage,…
The increasing recognition of High-Energy Visible Light (HEVL), particularly blue light, as a contributor to photoaging and cutaneous oxidative stress presents a significant challenge in dermatology and cosmetic research. HEVL exposure can induce cellular damage, leading to skin hyperpigmentation and…
Urban life comes with undeniable benefits, but also invisible costs. One of the most overlooked is how environmental pollutants interact with the skin, not just on its surface but within its living ecosystem: the microbiome. The microbiome is home to…
Air pollution constitutes a significant global health risk, contributing to increased morbidity and mortality. While the detrimental effects of airborne pollutants—such as ozone, particulate matter (PM10, PM2.5), volatile organic compounds (VOCs), and oxides—on internal organs are well-documented, the impact on…
Skin aging is recognized as a complex process influenced by intrinsic (genetically determined) and extrinsic (environmental factors like UV exposure, pollution, and lifestyle) factors. These processes lead to significant structural and functional changes in the skin, including reduced elasticity, loss…
The maintenance of skin strength and elasticity depends heavily on the extracellular matrix (ECM), which is composed primarily of elastin, hyaluronic acid, and collagen. Skin aging, driven by both extrinsic and intrinsic factors, is characterized by a reduction in ECM…
Effective topical treatment for nail fungal infection, or onychomycosis (ONC), faces significant hurdles primarily due to the poor permeation of active ingredients across the nail plate. The nail plate is a thick, hard keratin structure. ONC is responsible for 15%…
Hyperpigmentation disorders are prevalent and distressing conditions characterized by the excessive secretion of melanin in the epidermis and/or dermis. Among these, post-inflammatory hyperpigmentation (PIH), which involves skin darkening resulting from inflammation and subsequent activation of melanogenesis by inflammatory mediators, represents…
Monsoon brings relief from the scorching summer, but along with the refreshing showers comes a new set of challenges for skin health. Increased humidity, fluctuating temperatures, and heightened microbial activity all influence how skin behaves during the rainy season. Understanding…