Psoriasis, a chronic and immune-mediated skin disorder affecting millions worldwide, is driven by a complex interplay of genetic, environmental, and immune factors. The IL-17/IL-23 axis plays a central role in the disease’s pathogenesis, making it a critical target for therapeutic…
Porokeratoses are a diverse group of rare keratinization disorders that present unique clinical challenges. These disorders often manifest as papules progressing into annular plaques with central atrophy and scaling edges. Pathogenesis involves both genetic susceptibility and environmental triggers, including…
Introduction This study aimed to evaluate the potential of whole human saliva as an anti-acne agent against bacteria responsible for acne vulgaris (AV). Human saliva was selected due to its physiological and antioxidant properties, containing beneficial secretory molecules such as…
The skin, the body’s largest organ, plays a crucial role in protecting internal tissues and regulating moisture and body temperature. However, it also presents a significant barrier to the penetration of many compounds, especially due to the structure of the…
Halobacteria trueperi TCI66207, an extremophilic microorganism thriving in high-salt environments, produces extracellular polysaccharides known for their promising anti-inflammatory, antioxidant, and anti-aging properties. This study focuses on the strain H. trueperi TCI66207, isolated from the Pacific Ocean at a depth of 662 m…
Agave sisalana, traditionally used in folk medicine for treating various ailments, discards 95% of its leaf biomass as waste. This study explores the potential of its sapogenin-rich residue, particularly hecogenin and tigogenin, for anti-inflammatory and analgesic uses. Steroidal saponins from…
Jujube (Ziziphus jujuba Mill.) extracts are rich in antioxidants and have potential anti-aging effects, targeting fine lines, wrinkles, and skin hydration. Key components include antioxidants, fatty acids, vitamins, and polysaccharides, which improve skin texture, promote collagen synthesis, regulate inflammation, protect…
Skin aging, accelerated by UV-induced reactive oxygen species (ROS), leads to wrinkles and loss of elasticity. Astaxanthin and zeaxanthin (AZ-NE), potent antioxidants, offer significant protection against ROS and have potential in anti-aging skincare. This study evaluates the stability, skin penetration,…
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by epidermal barrier dysfunction, leading to increased transepidermal water loss and allergen entry, triggering inflammation. In India, AD affects 2.7% of children aged 6–7 years and 3.6% of adolescents aged…
Erlotinib, a tyrosine kinase inhibitor (EGFR-TKI), its use is frequently accompanied by significant cutaneous side effects, including facial dermatitis and hair loss. Previous research suggests that substance P (SP), a neuropeptide, is a major mediator of this skin toxicity. Given aprepitant’s…