Physical appearance, particularly related to the face, is a significant social factor, and the visible manifestation of age-related changes increasingly impacts psychological well-being. Reflecting this widespread concern, the global anti-aging skincare market was valued at USD 62.6 billion in 2021…
The global prevalence of allergic diseases has increased dramatically, paralleling the rapid urbanization and modernization that followed World War II. This shift toward urban living has led to a dramatic reduction in human exposure to biodiverse and natural environments. According…
Melasma is a chronic hyperpigmentation disorder that often proves resistant to therapy. It is recognized as one of the most challenging aesthetic defects to treat, characterized by irregular, well-demarcated discoloration spots typically found on the face, which intensify upon exposure…
Alopecia areata (AA) is a common, chronic autoimmune disorder characterized by non-scarring hair loss that significantly affects approximately 2% of the global population. The disease imposes a substantial psychosocial burden, often linked to anxiety and depression. Pathogenically, AA is driven…
The integrity of the skin’s protective and regulatory barrier function is primarily achieved within the stratum corneum (SC), the outermost layer of the epidermis. The SC utilizes a “brick-and-mortar” structure where corneocytes (bricks) are embedded in a matrix of highly…
Aging is a complex physiological process driven by diverse causes, frequently categorized into the “programmed theory” (congenital programming by genes) and the “accumulation of damage” to cellular components. Facial skin, in particular, is susceptible to damage, often resulting from UV…
Traditional and modern applications recognize the therapeutic potential of Sapindus mukorossi (S. mukorossi), commonly known as the soapnut tree, particularly for skin care and wound treatment. Extracts from the fruit pericarp and seed oil of S. mukorossi have shown promising…
The stratum corneum (SC), the skin’s outermost layer, is vital for maintaining skin barrier function, offering protection against physical and chemical damage and preventing transepidermal water loss. This protective structure is maintained by a layered architecture, where specialized intercellular adhesion…
Skin repair and anti-aging are established and vital research themes in dermatological and cosmetic science. As the largest immune organ, the skin gradually loses its physiological function and structural integrity due to internal (endogenous) factors like oxidative stress and inflammation,…
Interest in the process of aging and efforts to slow its progression have recently increased. Skin aging is a natural process characterized by a weakened skin barrier, reduced sebum production, and slower epidermal cell regeneration, leading to issues like discoloration,…