Maintaining skin integrity is a complex and crucial biological process, particularly as skin ages or becomes compromised, where effective wound healing and barrier restoration are vital for overall health and protection against environmental stressors, dehydration, and pathogens. Impaired wound healing,…
The modern cosmetics industry faces an increasing demand for natural, multifunctional dermocosmetic formulations, especially those that offer antioxidant and photoprotective benefits. Traditional synthetic ingredients often raise concerns regarding their environmental impact and potential health effects, driving a shift towards sustainable,…
Tyrosinase, a copper-dependent oxidase, plays a pivotal role in melanin biosynthesis, catalyzing the conversion of tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA) and subsequently to dopaquinone, which leads to melanin formation. While melanin is essential for skin, hair, and eye coloration and provides…
Photoaging is a progressive and multifactorial skin aging process primarily triggered by prolonged exposure to ultraviolet (UV) radiation. This condition results in significant structural and functional impairments in the skin, including the formation of wrinkles, loss of elasticity, pigmentation irregularities,…
Tyrosinase is a crucial multifunctional enzyme that catalyzes the oxidation of phenolic compounds, playing a significant physiological role in humans. Imbalances or dysregulated expression of this enzyme can lead to various skin disorders, including melanoma, freckles, chloasma, and vitiligo. Given…
Skin aging is a complex biological process influenced by a combination of intrinsic (genetic factors, hormonal fluctuations, cellular senescence) and extrinsic factors (UV radiation, pollution, smoking, diet). These factors lead to visible changes such as wrinkles, loss of elasticity, uneven…
Epidermal Growth Factor (EGF) is a highly promising molecule for the cosmetic industry due to its biological functions, which include promoting cell growth, proliferation, differentiation, and survival, as well as stimulating collagen synthesis and accelerating wound healing processes. These properties…
Atopic dermatitis (AD) is a widespread, chronic inflammatory skin condition affecting millions globally, including children and adolescents, significantly impacting patients’ quality of life. It is characterized by impaired skin barrier function, leading to intense itching (pruritus), dry skin (xerosis), and…
Hydrogels represent a promising class of drug carriers for dermatological applications. They are characterized as specific, three-dimensional hydrophilic networks of polymers that maintain a stable structure despite high water content. Their favorable properties, such as plasticity, bio- and mucoadhesiveness, good…
The skin, serving as the body’s primary barrier, is constantly exposed to various environmental aggressors, with ultraviolet radiation (UVR) being one of the most significant threats. Long-term exposure to UVR is a major contributor to skin aging (photoaging) and carcinogenesis,…